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Description

Rare variant analysis has revealed that loss-of-function mutations within activating transcription factor 4 (ATF4), a transcription factor responsible for the upregulation of serine synthesis under conditions of serine starvation, are associated with higher risk for PAH, which further suggests serine is closely related PAH

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The authors thank AI + High Performance Computing Center of ZJU-ICI for their support in molecular dynamics simulations

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